IL13RA2

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.^[5]

IL13RA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LB6
Identifiers
Aliases	IL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
External IDs	OMIM: 300130; MGI: 1277954; HomoloGene: 534; GeneCards: IL13RA2; OMA:IL13RA2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq23 Start 115,003,975 bp[1] End 115,019,977 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F2|X 68.46 cM Start 146,166,472 bp[2] End 146,212,188 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Descending thoracic aorta ascending aorta right testis left testis gonad glomerulus metanephric glomerulus testicle anterior pituitary Top expressed in cumulus cell pineal gland mesenteric lymph nodes uterus lip gastrula ascending aorta aortic valve dentate gyrus of hippocampal formation granule cell skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity signal transducer activity protein binding cytokine binding Cellular component integral component of membrane membrane extracellular region extracellular space external side of plasma membrane receptor complex Biological process negative regulation of mast cell degranulation negative regulation of immunoglobulin production immunoglobulin mediated immune response cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3598 16165 Ensembl ENSG00000123496 ENSMUSG00000031289 UniProt Q14627 O88786 RefSeq (mRNA) NM_000640 NM_008356 NM_001306059 RefSeq (protein) NP_000631 NP_001292988 NP_032382 Location (UCSC) Chr X: 115 – 115.02 Mb Chr X: 146.17 – 146.21 Mb PubMed search [3] [4]
Wikidata
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Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.^[5]

Clinical Significance

IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas. ^[6][7][8][9]

See also

• Interleukin-13 receptor