CD38-IN-78c

CD38-IN-78c is a drug which acts as a potent and selective inhibitor of the glycoprotein enzyme CD38.^[1] In animal studies it boosts levels of nicotinamide adenine dinucleotide (NAD+) in tissues via inhibition of CD38 mediated breakdown of nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), and has been shown to ameliorate metabolic dysfunction associated with the aging process.^[2] It also has potential therapeutic application in the treatment of Alzheimer's disease.^[3]

CD38-IN-78c

Identifiers
IUPAC name 4-{[(1R,4R)-4-(2-methoxyethoxy)cyclohexyl]amino}-1-methyl-6-(1,3-thiazol-5-yl)quinolin-2-one
CAS Number	1700637-55-3
PubChem CID	118736856
ChemSpider	107562966
ChEMBL	ChEMBL3426034
Chemical and physical data
Formula	C22H27N3O3S
Molar mass	413.54 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1C2=C(C=C(C=C2)C3=CN=CS3)C(=CC1=O)NC4CCC(CC4)OCCOC
InChI InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3 Key:VJQALSOBHVEJQM-UHFFFAOYSA-N