Glycoprotein IX

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.^[5]

GP9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3REZ
Identifiers
Aliases	GP9, CD42a, GPIX, Glycoprotein IX, glycoprotein IX platelet
External IDs	OMIM: 173515; MGI: 1860137; HomoloGene: 144; GeneCards: GP9; OMA:GP9 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 129,060,779 bp[1] End 129,062,406 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 39.13 cM Start 87,755,054 bp[2] End 87,756,750 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood right lung spleen bone marrow upper lobe of left lung bone marrow cells mucosa of nose olfactory zone of nasal mucosa Top expressed in blood fetal liver hematopoietic progenitor cell tibiofemoral joint spleen embryo granulocyte morula yolk sac right lung morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process platelet activation blood coagulation, intrinsic pathway hemostasis cell adhesion blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2815 54368 Ensembl ENSG00000169704 ENSMUSG00000030054 UniProt P14770 O88186 RefSeq (mRNA) NM_000174 NM_018762 RefSeq (protein) NP_000165 NP_061232 Location (UCSC) Chr 3: 129.06 – 129.06 Mb Chr 6: 87.76 – 87.76 Mb PubMed search [3] [4]
Wikidata
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Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM]^[5]

See also

• Cluster of differentiation