GP5 (gene)

This article is about the glycoprotein V. For the GP5 computer chip, see GP5 chip. For the Soviet-era civilian gas mask, see GP-5 gas mask.

Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a human gene.^[5]

GP5
Identifiers
Aliases	GP5, CD42d, GPV, glycoprotein V platelet
External IDs	OMIM: 173511; MGI: 1096363; HomoloGene: 74523; GeneCards: GP5; OMA:GP5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 194,394,821 bp[1] End 194,399,266 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B2 Start 30,126,503 bp[2] End 30,129,597 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte trabecular bone right uterine tube bronchial epithelial cell granulocyte lymph node blood appendix bone marrow gallbladder Top expressed in tibiofemoral joint blood morula blastocyst embryo spleen embryo yolk sac abdominal wall bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane extracellular space Biological process platelet activation blood coagulation, intrinsic pathway hemostasis cell adhesion blood coagulation axonogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2814 14729 Ensembl ENSG00000178732 ENSMUSG00000047953 UniProt P40197 O08742 Q9QZU3 RefSeq (mRNA) NM_004488 NM_008148 RefSeq (protein) NP_004479 NP_032174 Location (UCSC) Chr 3: 194.39 – 194.4 Mb Chr 16: 30.13 – 30.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 193400) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder.[supplied by OMIM]^[5]

See also

• Cluster of differentiation