CEACAM8

Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b (Cluster of Differentiation 66b), is a member of the carcinoembryonic antigen (CEA) gene family. Its main function is cell adhesion, cell migration, and pathogen binding.^[3]

CEACAM8
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2DKS, 4Y88, 4YIQ, 4WTZ
Identifiers
Aliases	CEACAM8, CD66b, CD67, CGM6, NCA-95, carcinoembryonic antigen related cell adhesion molecule 8, CEA cell adhesion molecule 8
External IDs	OMIM: 615747; HomoloGene: 68205; GeneCards: CEACAM8; OMA:CEACAM8 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 42,580,243 bp[1] End 42,595,055 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone bone marrow bone marrow cells testicle mononuclear cell monocyte blood granulocyte spleen mucosa of transverse colon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein heterodimerization activity Cellular component anchored component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane extracellular space azurophil granule membrane specific granule membrane tertiary granule membrane cell surface Biological process immune response leukocyte migration neutrophil degranulation cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1088 n/a Ensembl ENSG00000124469 n/a UniProt P31997 n/a RefSeq (mRNA) NM_001816 n/a RefSeq (protein) NP_001807 n/a Location (UCSC) Chr 19: 42.58 – 42.6 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Use

CEACAM8 is expressed exclusively on granulocytes and used as granulocyte marker.

See also

• Cluster of differentiation