CEACAM5

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.^[3]

CEACAM5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1E07, 2QSQ, 2QST, 2VER
Identifiers
Aliases	CEACAM5, CD66e, CEA, carcinoembryonic antigen related cell adhesion molecule 5, CEA cell adhesion molecule 5
External IDs	OMIM: 114890; HomoloGene: 128801; GeneCards: CEACAM5; OMA:CEACAM5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,708,585 bp[1] End 41,730,433 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of sigmoid colon nasal epithelium rectum mucosa of transverse colon mucosa of pharynx appendix oral cavity palpebral conjunctiva trachea n/a More reference expression data BioGPS n/a
Gene ontology Molecular function GPI anchor binding protein homodimerization activity identical protein binding Cellular component anchored component of membrane basolateral plasma membrane integral component of plasma membrane extracellular exosome membrane integral component of external side of plasma membrane extracellular region plasma membrane cell surface apical plasma membrane Biological process homotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of anoikis negative regulation of myotube differentiation C-terminal protein lipidation leukocyte migration apoptotic process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1048 n/a Ensembl ENSG00000105388 n/a UniProt P06731 n/a RefSeq (mRNA) NM_001291484 NM_001308398 NM_004363 n/a RefSeq (protein) NP_001278413 NP_001295327 NP_004354 n/a Location (UCSC) Chr 19: 41.71 – 41.73 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Functions

In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.^[4][5] Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.^[6] Also, it plays a significant role in the inhibition of differentiation ^[7] and apoptosis ^[8] in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.^[9] High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).^[10][11]

See also

• Cluster of differentiation