LILRB5

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.^[3][4]

LILRB5
Identifiers
Aliases	LILRB5, CD85C, LIR-8, LIR8, leukocyte immunoglobulin like receptor B5
External IDs	OMIM: 604814; HomoloGene: 134027; GeneCards: LILRB5; OMA:LILRB5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,249,421 bp[1] End 54,257,301 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen thymus subcutaneous adipose tissue right adrenal cortex left adrenal gland left adrenal cortex placenta duodenum right coronary artery gastric mucosa n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity Cellular component integral component of membrane membrane Biological process defense response cell surface receptor signaling pathway adaptive immune response immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10990 n/a Ensembl ENSG00000274311 ENSG00000278437 ENSG00000273991 ENSG00000277414 ENSG00000105609 n/a n/a UniProt O75023 n/a RefSeq (mRNA) NM_001081442 NM_001081443 NM_001304457 NM_006840 n/a RefSeq (protein) NP_001074911 NP_001074912 NP_001291386 NP_006831 n/a Location (UCSC) Chr 19: 54.25 – 54.26 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]