LILRB2

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.^[3][4][5]

LILRB2
Identifiers
Aliases	LILRB2, ILT4, MIR10, LIR2, MIR-10, LIR-2, leukocyte immunoglobulin like receptor B2, ILT-4, CD85D
External IDs	OMIM: 604815; HomoloGene: 136797; GeneCards: LILRB2; OMA:LILRB2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,273,812 bp[1] End 54,281,184 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood spleen appendix bone marrow bone marrow cells right lung upper lobe of left lung testicle n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10288 n/a Ensembl ENSG00000274513 ENSG00000275463 ENSG00000131042 ENSG00000276146 ENSG00000277751 n/a n/a UniProt A2IXV5 n/a RefSeq (mRNA) NM_001080978 NM_001278403 NM_001278404 NM_001278405 NM_001278406 NM_005874 n/a RefSeq (protein) NP_001074447 NP_001265332 NP_001265333 NP_001265334 NP_001265335 NP_005865 n/a Location (UCSC) Chr 19: 54.27 – 54.28 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]

LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury.^[6] However, recent studies demonstrate that LILRB2 is a β-Amyloid receptor and may contribute to synaptic loss and cognitive impairment in Alzheimer's disease.^[7][8]

Interactions

LILRB2 has been shown to interact with PTPN6.^[9][10]

See also

• Cluster of differentiation