LILRA4

Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.^[3][4]

LILRA4
Identifiers
Aliases	LILRA4, CD85g, ILT7, leukocyte immunoglobulin like receptor A4
External IDs	OMIM: 607517; HomoloGene: 69118; GeneCards: LILRA4; OMA:LILRA4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,333,185 bp[1] End 54,339,162 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen testicle lymph node monocyte blood appendix C1 segment gonad substantia nigra n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signaling receptor binding coreceptor activity Cellular component membrane integral component of membrane integral component of plasma membrane Fc-epsilon receptor I complex plasma membrane Biological process immune system process negative regulation of interferon-alpha production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor 7 signaling pathway negative regulation of toll-like receptor 9 signaling pathway Fc-epsilon receptor signaling pathway innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23547 n/a Ensembl ENSG00000277092 ENSG00000276798 ENSG00000274185 ENSG00000239961 n/a UniProt P59901 n/a RefSeq (mRNA) NM_012276 n/a RefSeq (protein) NP_036408 n/a Location (UCSC) Chr 19: 54.33 – 54.34 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.^[4]