LILRA2

Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.^[3][4][5]

LILRA2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2OTP
Identifiers
Aliases	LILRA2, CD85H, ILT1, LIR-7, LIR7, leukocyte immunoglobulin like receptor A2
External IDs	OMIM: 604812; HomoloGene: 68534; GeneCards: LILRA2; OMA:LILRA2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,572,920 bp[1] End 54,590,287 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte monocyte spleen bone marrow bone marrow cells appendix right lung upper lobe of left lung C1 segment n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antigen binding IgM binding signaling receptor activity Cellular component integral component of membrane extracellular region membrane integral component of plasma membrane plasma membrane Biological process defense response signal transduction immune system process innate immune response activating cell surface receptor signaling pathway neutrophil activation involved in immune response negative regulation of lipopolysaccharide-mediated signaling pathway granulocyte macrophage colony-stimulating factor production interleukin-6 production interleukin-8 production negative regulation of toll-like receptor 4 signaling pathway granulocyte colony-stimulating factor production innate immune response positive regulation of cell activation positive regulation of calcium ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11027 n/a Ensembl ENSG00000239998 ENSG00000274000 ENSG00000275290 ENSG00000278634 n/a UniProt Q8N149 n/a RefSeq (mRNA) NM_001130917 NM_001290270 NM_001290271 NM_006866 n/a RefSeq (protein) NP_001124389 NP_001277199 NP_001277200 NP_006857 n/a Location (UCSC) Chr 19: 54.57 – 54.59 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM]^[5]

Function

LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.^[6]

See also

• Cluster of differentiation