Cyclin-dependent kinase 3

"CDK3" redirects here. For the IATA airport code, see Dorset/Kawagama Lake (South) Water Aerodrome.

Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene.^[3][4]

CDK3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1LFN
Identifiers
Aliases	CDK3, cyclin dependent kinase 3
External IDs	OMIM: 123828; HomoloGene: 74387; GeneCards: CDK3; OMA:CDK3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,000,855 bp[1] End 76,005,999 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver granulocyte pituitary gland right lobe of thyroid gland right uterine tube anterior pituitary gonad prostate spleen n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activity ATP binding kinase activity nucleotide binding protein kinase activity transferase activity cyclin-dependent protein serine/threonine kinase activity protein binding cyclin binding Cellular component cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm Biological process cell division cell population proliferation cell cycle G0 to G1 transition cellular response to DNA damage stimulus phosphorylation protein phosphorylation signal transduction multicellular organism development positive regulation of cell population proliferation response to organic substance regulation of G2/M transition of mitotic cell cycle regulation of gene expression G1/S transition of mitotic cell cycle regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1018 n/a Ensembl ENSG00000250506 n/a UniProt Q00526 n/a RefSeq (mRNA) NM_001258 n/a RefSeq (protein) NP_001249 n/a Location (UCSC) Chr 17: 76 – 76.01 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

CDK3 complements cdc28 mutants of Saccharomyces cerevisiae suggesting that it may be involved in cell cycle control. CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin.^[4]