Corneodesmosin

Corneodesmosin is a protein that in humans is encoded by the CDSN gene.^[5][6][7]

CDSN
Identifiers
Aliases	CDSN, D6S586E, HTSS, HTSS1, HYPT2, PSS, PSS1, corneodesmosin, S
External IDs	OMIM: 602593; MGI: 3505689; HomoloGene: 48005; GeneCards: CDSN; OMA:CDSN - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,115,087 bp[1] End 31,120,446 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 35,863,025 bp[2] End 35,868,077 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg testicle placenta gastrocnemius muscle vagina skeletal muscle tissue tonsil gallbladder duodenum Top expressed in lip skin of external ear esophagus skin of back superior surface of tongue skin of abdomen subcutaneous adipose tissue white adipose tissue cervix gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity Cellular component extracellular region desmosome cell-cell junction cornified envelope plasma membrane Biological process cell adhesion skin morphogenesis keratinocyte differentiation epidermis development cornification corneocyte desquamation negative regulation of cornification cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1041 386463 Ensembl ENSG00000204539 ENSMUSG00000039518 UniProt Q15517 Q7TPC1 RefSeq (mRNA) NM_001264 NM_001008424 NM_001355275 RefSeq (protein) NP_001255 NP_001008424 NP_001342204 Location (UCSC) Chr 6: 31.12 – 31.12 Mb Chr 17: 35.86 – 35.87 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein found in corneodesmosomes, which localize to the human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.^[7]

See also

• Hypertrichosis simplex of the scalp
• List of conditions caused by problems with junctional proteins