Centromere protein B

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.^[5][6][7]

CENPB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UFI, 1BW6, 1HLV
Identifiers
Aliases	CENPB, entrez:1059, centromere protein B
External IDs	OMIM: 117140; MGI: 88376; HomoloGene: 1370; GeneCards: CENPB; OMA:CENPB - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,783,851 bp[1] End 3,786,740 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.29 cM Start 131,017,102 bp[2] End 131,021,987 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment amygdala apex of heart gastrocnemius muscle putamen muscle of thigh stromal cell of endometrium nipple inferior ganglion of vagus nerve nucleus accumbens Top expressed in muscle of thigh lip parotid gland dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord superior frontal gyrus skin of external ear lacrimal gland extensor digitorum longus muscle ventricular zone More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 1059 12616 Ensembl ENSG00000125817 ENSMUSG00000068267 UniProt P07199 P27790 RefSeq (mRNA) NM_001810 NM_007682 RefSeq (protein) NP_001801 NP_031708 Location (UCSC) Chr 20: 3.78 – 3.79 Mb Chr 2: 131.02 – 131.02 Mb PubMed search [3] [4]
Wikidata
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Function

Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Clinical significance

Centromere protein B is a potential biomarker of small-cell lung cancer.^[8]

See also

• Centromere