Centromere protein E

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.^[5][6]

CENPE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T5C
Identifiers
Aliases	CENPE, CENP-E, KIF10, PPP1R61, MCPH13, Centromere protein E
External IDs	OMIM: 117143; MGI: 1098230; HomoloGene: 20429; GeneCards: CENPE; OMA:CENPE - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 103,105,349 bp[1] End 103,198,445 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 62.55 cM Start 134,918,298 bp[2] End 134,979,372 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ventricular zone testicle secondary oocyte ganglionic eminence gonad trabecular bone bone marrow stromal cell of endometrium bone marrow cell Top expressed in zygote secondary oocyte genital tubercle tail of embryo maxillary prominence ventricular zone primary oocyte mandibular prominence abdominal wall vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity ATP binding protein binding microtubule motor activity microtubule binding kinetochore binding Cellular component spindle kinesin complex chromosome nucleus outer kinetochore chromosome, centromeric region membrane midbody microtubule kinetochore condensed chromosome, centromeric region microtubule cytoskeleton mitotic spindle midzone cytoskeleton cytoplasm cytosol kinetochore microtubule nucleoplasm spindle midzone Biological process regulation of mitotic metaphase/anaphase transition cell cycle positive regulation of protein kinase activity multicellular organism development cell division antigen processing and presentation of exogenous peptide antigen via MHC class II kinetochore assembly microtubule-based movement sister chromatid cohesion retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum metaphase plate congression lateral attachment of mitotic spindle microtubules to kinetochore mitotic cell cycle mitotic spindle organization mitotic chromosome movement towards spindle pole microtubule plus-end directed mitotic chromosome migration chromosome segregation mitotic metaphase plate congression attachment of mitotic spindle microtubules to kinetochore Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1062 229841 Ensembl ENSG00000138778 ENSMUSG00000045328 UniProt Q02224 Q6RT24 RefSeq (mRNA) NM_001286734 NM_001813 NM_173762 RefSeq (protein) NP_001273663 NP_001804 NP_776123 Location (UCSC) Chr 4: 103.11 – 103.2 Mb Chr 3: 134.92 – 134.98 Mb PubMed search [3] [4]
Wikidata
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Centromere-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.^[6]

CENPE is also called Kinesin-7.

Clinical significance

Mutations in CENPE result in autosomal recessive primary microcephaly type 13, which includes skeletal abnormalities and immunodeficiency.^[7]

See also

• CENPF
• CENPJ
• CENPT