CGP 52608

CGP 52608 is a selective ligand of the RAR-related orphan receptor alpha.^[1] It has been used as a biochemical tool to investigate nuclear and membrane signaling of melatonin.^[1] CGP 52608 has also been reported to possess antiarthritic activity.^[2] The pharmaceutical company Novartis brought it to clinical trials for rheumatoid arthritis, but development was discontinued in 2006.^[3]

CGP 52608

Names
IUPAC name 3-Methyl-1-[(4-oxo-3-prop-2-enyl-1,3-thiazolidin-2-ylidene)amino]thiourea
Identifiers
CAS Number	87958-67-6
3D model (JSmol)	Interactive image
ChemSpider	4589397
PubChem CID	6509863
UNII	QS3ABF85TR Y
InChI InChI=1/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8- Key: DDYJDIHOSRTMSE-FLIBITNWBI
SMILES S=C(N\N=C1/SCC(=O)N1C\C=C)NC
Properties
Chemical formula	C8H12N4OS2
Molar mass	244.33 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

CGP 52608 contains a thiazolinidinedione group.^[4]