Chimerin 2

Chimerin 2 (beta-chimaerin) is a protein that in humans is encoded by the CHN2 gene.^[4][5]

CHN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XA6
Identifiers
Aliases	CHN2, ARHGAP3, BCH, CHN2-3, RHOGAP3, chimerin 2
External IDs	OMIM: 602857; MGI: 1917243; HomoloGene: 31213; GeneCards: CHN2; OMA:CHN2 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse)[1] Band 6|6 B3 Start 54,016,539 bp[1] End 54,278,795 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in lobe of cerebellum cerebellar vermis seminiferous tubule olfactory tubercle spermatid zygote nucleus accumbens lateral septal nucleus pontine nuclei interventricular septum BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity Cellular component cytoplasm cytosol membrane Biological process intracellular signal transduction regulation of small GTPase mediated signal transduction signal transduction positive regulation of signal transduction positive regulation of GTPase activity regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1124 69993 Ensembl ENSG00000106069 ENSMUSG00000004633 UniProt P52757 Q80XD1 RefSeq (mRNA) NM_001039936 NM_001293069 NM_001293070 NM_001293071 NM_001293072 NM_001293073 NM_001293075 NM_001293076 NM_001293077 NM_001293078 NM_001293079 NM_001293080 NM_001293081 NM_004067 NM_001398427 NM_001163640 NM_023543 NM_001311133 NM_001311134 RefSeq (protein) NP_001035025 NP_001279998 NP_001279999 NP_001280000 NP_001280001 NP_001280002 NP_001280004 NP_001280005 NP_001280006 NP_001280007 NP_001280008 NP_001280009 NP_001280010 NP_004058 NP_001157112 NP_001298062 NP_001298063 NP_076032 Location (UCSC) n/a Chr 6: 54.02 – 54.28 Mb PubMed search [2] [3]
Wikidata
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This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/diacylglycerol-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5]