CLEC1B

C-type lectin domain family 1 member B (i.e., CLEC-1b), also termed C-type lectin-like receptor 2 (i.e., CLEC-2),^[5] is a protein that in humans is encoded by the CLEC1B gene.^[6][7][8]

CLEC1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C6U, 3WSR, 3WWK
Identifiers
Aliases	CLEC1B, 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B
External IDs	OMIM: 606783; MGI: 1913287; HomoloGene: 49468; GeneCards: CLEC1B; OMA:CLEC1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31-p13.2 Start 9,985,642 bp[1] End 10,013,424 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 129,374,260 bp[2] End 129,386,298 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte testicle liver right lobe of liver granulocyte trabecular bone blood bone marrow buccal mucosa cell bone marrow cells Top expressed in blood tibiofemoral joint spleen mesenteric lymph nodes granulocyte hepatobiliary system liver embryo right lung right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding carbohydrate binding transmembrane signaling receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process platelet activation defense response cell surface receptor signaling pathway platelet formation signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51266 56760 Ensembl ENSG00000165682 ENSMUSG00000030159 UniProt Q9P126 Q9JL99 RefSeq (mRNA) NM_001099431 NM_016509 NM_001393342 NM_001204239 NM_001204253 NM_019985 RefSeq (protein) NP_001092901 NP_057593 NP_001191168 NP_001191182 NP_064369 Location (UCSC) Chr 12: 9.99 – 10.01 Mb Chr 6: 129.37 – 129.39 Mb PubMed search [3] [4]
Wikidata
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Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]^[8]