Calmegin

Calmegin, also known as CLGN, is a protein which in humans is encoded by the CLGN gene.^[5] Calmegin is also present in other animals including mice.^[6]

CLGN
Identifiers
Aliases	CLGN, calmegin
External IDs	OMIM: 601858; MGI: 107472; HomoloGene: 68392; GeneCards: CLGN; OMA:CLGN - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.1 Start 140,388,453 bp[1] End 140,427,661 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 39.97 cM Start 84,116,496 bp[2] End 84,155,181 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle myocardium of left ventricle left testis right testis cardiac muscle tissue of right atrium right auricle of heart endothelial cell islet of Langerhans apex of heart retinal pigment epithelium Top expressed in spermatocyte spermatid seminiferous tubule olfactory epithelium lumbar spinal ganglion trigeminal ganglion facial motor nucleus anterior horn of spinal cord medulla oblongata substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein folding chaperone activity calcium ion binding protein binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum nuclear envelope Biological process protein folding single fertilization binding of sperm to zona pellucida protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1047 12745 Ensembl ENSG00000153132 ENSMUSG00000002190 UniProt O14967 P52194 RefSeq (mRNA) NM_001130675 NM_004362 NM_009904 NM_001329627 NM_001329680 RefSeq (protein) NP_001124147 NP_004353 NP_001316556 NP_001316609 NP_034034 Location (UCSC) Chr 4: 140.39 – 140.43 Mb Chr 8: 84.12 – 84.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility.^[5]