CMP kinase

UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene.^[5][6]

CMPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TEV
Identifiers
Aliases	CMPK1, CK, CMK, CMPK, UMK, UMP-CMPK, UMPK, cytidine/uridine monophosphate kinase 1
External IDs	OMIM: 191710; MGI: 1913838; HomoloGene: 32308; GeneCards: CMPK1; OMA:CMPK1 - orthologs
EC number	2.7.4.6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p33 Start 47,333,790 bp[1] End 47,378,839 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 114,816,533 bp[2] End 114,844,438 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa palpebral conjunctiva parotid gland mucosa of sigmoid colon duodenum rectum epithelium of nasopharynx tibia oral cavity Achilles tendon Top expressed in saccule otic placode otic vesicle left colon olfactory epithelium gastric mucosa mucous cell of stomach epithelium of stomach crypt of lieberkuhn of small intestine intestinal villus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding uridylate kinase activity kinase activity nucleobase-containing compound kinase activity uridine kinase activity nucleoside diphosphate kinase activity ATP binding cytidylate kinase activity nucleoside monophosphate kinase activity Cellular component cytoplasm cytosol extracellular exosome nucleus nucleolus Biological process nucleobase-containing small molecule interconversion phosphorylation nucleoside diphosphate phosphorylation pyrimidine ribonucleotide biosynthetic process pyrimidine nucleotide biosynthetic process 'de novo' pyrimidine nucleobase biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound metabolic process nucleoside monophosphate phosphorylation UMP biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51727 66588 Ensembl ENSG00000162368 ENSMUSG00000028719 UniProt P30085 Q9DBP5 RefSeq (mRNA) NM_001136140 NM_016308 NM_001366135 NM_025647 RefSeq (protein) NP_001129612 NP_057392 NP_001353064 NP_079923 Location (UCSC) Chr 1: 47.33 – 47.38 Mb Chr 4: 114.82 – 114.84 Mb PubMed search [3] [4]
Wikidata
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Function

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.^[6][7]