Contactin 2

Contactin-2 is a protein that in humans is encoded by the CNTN2 gene.^[5][6][7]

CNTN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OM5
Identifiers
Aliases	CNTN2, AXT, FAME5, TAG-1, TAX, TAX1, contactin 2, transient axonal glycoprotein-1
External IDs	OMIM: 190197; MGI: 104518; HomoloGene: 3720; GeneCards: CNTN2; OMA:CNTN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,042,937 bp[1] End 205,078,289 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 132,437,165 bp[2] End 132,470,994 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve C1 segment corpus callosum internal globus pallidus subthalamic nucleus pars reticulata ventral tegmental area superior vestibular nucleus external globus pallidus pons Top expressed in cerebellar cortex superior frontal gyrus primary visual cortex trigeminal ganglion cerebellar vermis ganglionic eminence lobe of cerebellum central gray substance of midbrain deep cerebellar nuclei pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein self-association identical protein binding carbohydrate binding cell-cell adhesion mediator activity Cellular component membrane myelin sheath voltage-gated potassium channel complex plasma membrane node of Ranvier synapse integral component of plasma membrane cell surface axon soma anchored component of membrane neuron projection juxtaparanode region of axon anchored component of postsynaptic membrane Biological process clustering of voltage-gated potassium channels negative regulation of neuron differentiation central nervous system myelination receptor internalization neuron migration learning presynaptic membrane organization regulation of astrocyte differentiation regulation of axon diameter cell adhesion positive regulation of protein processing establishment of protein localization to juxtaparanode region of axon positive regulation of adenosine receptor signaling pathway cerebral cortex GABAergic interneuron migration regulation of neuronal synaptic plasticity protein localization to juxtaparanode region of axon regulation of cell morphogenesis involved in differentiation neuron projection development axonal fasciculation microtubule cytoskeleton organization adult walking behavior axon guidance nervous system development homophilic cell adhesion via plasma membrane adhesion molecules dendrite self-avoidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6900 21367 Ensembl ENSG00000184144 ENSMUSG00000053024 UniProt Q02246 Q61330 RefSeq (mRNA) NM_005076 NM_001346083 NM_011531 NM_177129 RefSeq (protein) NP_001333012 NP_005067 NP_796103 Location (UCSC) Chr 1: 205.04 – 205.08 Mb Chr 1: 132.44 – 132.47 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.^[7]

Interactions

CNTN2 has been shown to interact with CNTNAP2^[8] and NFYB.^[9]