Collagen, type XVI, alpha 1

Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene.^[5][6]

COL16A1
Identifiers
Aliases	COL16A1, 447AA, FP1572, collagen type XVI alpha 1, collagen type XVI alpha 1 chain
External IDs	OMIM: 120326; MGI: 1095396; HomoloGene: 1397; GeneCards: COL16A1; OMA:COL16A1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 31,652,263 bp[1] End 31,704,319 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 129,941,633 bp[2] End 129,993,076 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia cartilage tissue left ovary canal of the cervix sural nerve C1 segment right ovary right coronary artery body of uterus periodontal fiber Top expressed in body of femur umbilical cord calvaria vas deferens seminiferous tubule uterus lip spermatocyte efferent ductule dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding protein binding extracellular matrix structural constituent extracellular matrix structural constituent conferring tensile strength Cellular component extracellular region collagen type XVI trimer collagen endoplasmic reticulum lumen extracellular matrix extracellular space collagen-containing extracellular matrix Biological process cellular response to amino acid stimulus integrin-mediated signaling pathway female pregnancy positive regulation of focal adhesion assembly integrin activation cell adhesion extracellular matrix organization cell adhesion mediated by integrin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1307 107581 Ensembl ENSG00000084636 ENSMUSG00000040690 UniProt Q07092 Q8BLX7 RefSeq (mRNA) NM_001856 NM_028266 RefSeq (protein) NP_001847 NP_082542 NP_001391281 NP_001391282 Location (UCSC) Chr 1: 31.65 – 31.7 Mb Chr 4: 129.94 – 129.99 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.^[6]