Collagen, type XXV, alpha 1

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.^[5][6]

COL25A1
Identifiers
Aliases	COL25A1, AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1, collagen type XXV alpha 1 chain
External IDs	OMIM: 610004; MGI: 1924268; HomoloGene: 57111; GeneCards: COL25A1; OMA:COL25A1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 108,808,725 bp[1] End 109,302,752 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 129,925,150 bp[2] End 130,393,526 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis jejunal mucosa buccal mucosa cell testicle Achilles tendon subcutaneous adipose tissue anterior pituitary sural nerve Top expressed in median eminence lateral septal nucleus medial dorsal nucleus arcuate nucleus substantia nigra habenula superior colliculus lateral geniculate nucleus anterior amygdaloid area lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function heparin binding amyloid-beta binding extracellular matrix structural constituent extracellular matrix structural constituent conferring tensile strength Cellular component integral component of membrane extracellular region plasma membrane collagen endoplasmic reticulum lumen membrane extracellular space integral component of plasma membrane extracellular matrix collagen-containing extracellular matrix Biological process axonogenesis involved in innervation extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84570 77018 Ensembl ENSG00000188517 ENSMUSG00000058897 UniProt Q9BXS0 Q99MQ5 RefSeq (mRNA) NM_001256074 NM_032518 NM_198721 NM_001244952 NM_029838 NM_198711 RefSeq (protein) NP_001243003 NP_115907 NP_942014 NP_001231881 NP_084114 NP_942004 Location (UCSC) Chr 4: 108.81 – 109.3 Mb Chr 3: 129.93 – 130.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM]^[6]

Interactions

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.^[5]