Collectin-12

Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene.^[5]

COLEC12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OX8
Identifiers
Aliases	COLEC12, CLP1, NSR2, SCARA4, SRCL, collectin subfamily member 12
External IDs	OMIM: 607621; MGI: 2152907; HomoloGene: 34248; GeneCards: COLEC12; OMA:COLEC12 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.32 Start 316,737 bp[1] End 500,722 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 9,707,595 bp[2] End 9,882,644 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint tibia synovial membrane tendon of biceps brachii retinal pigment epithelium placenta skin of hip periodontal fiber pericardium cartilage tissue Top expressed in basilar part of occipital bone mesothelium of peritoneum sphenoid bone calvaria basisphenoid pericardium vestibular sensory epithelium external carotid artery rib pleura More reference expression data BioGPS n/a
Gene ontology Molecular function pattern recognition receptor activity galactose binding metal ion binding low-density lipoprotein particle binding scavenger receptor activity carbohydrate binding Cellular component integral component of membrane endocytic vesicle membrane collagen membrane plasma membrane extracellular space extracellular matrix Biological process defense response positive regulation of cell adhesion molecule production carbohydrate mediated signaling receptor-mediated endocytosis immune response cellular response to exogenous dsRNA phagocytosis, recognition innate immune response toll-like receptor 3 signaling pathway protein homooligomerization regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81035 140792 Ensembl ENSG00000158270 ENSMUSG00000036103 UniProt Q5KU26 Q8K4Q8 RefSeq (mRNA) NM_030781 NM_130386 NM_130449 RefSeq (protein) NP_569057 NP_569716 Location (UCSC) Chr 18: 0.32 – 0.5 Mb Chr 18: 9.71 – 9.88 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the collectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].