Cartilage oligomeric matrix protein

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.^[5][6][7]

COMP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FBY
Identifiers
Aliases	COMP, EDM1, EPD1, MED, PSACH, THBS5, cartilage oligomeric matrix protein, TSP5, CTS2
External IDs	OMIM: 600310; MGI: 88469; HomoloGene: 74; GeneCards: COMP; OMA:COMP - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,782,773 bp[1] End 18,791,305 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.15 cM Start 70,826,208 bp[2] End 70,834,716 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia cartilage tissue Achilles tendon tendon of biceps brachii synovial joint popliteal artery tibial arteries saphenous vein urethra ascending aorta Top expressed in ankle tibiofemoral joint fossa trachea intercostal muscle seminiferous tubule condyle spermatid skin of external ear calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding calcium ion binding heparan sulfate proteoglycan binding heparin binding extracellular matrix structural constituent protein binding collagen binding integrin binding BMP binding proteoglycan binding Cellular component extracellular matrix extracellular exosome extracellular space extracellular region protein-containing complex collagen-containing extracellular matrix Biological process animal organ morphogenesis growth plate cartilage development skeletal system development cell adhesion extracellular matrix organization negative regulation of apoptotic process limb development apoptotic process ossification chondrocyte development endochondral bone growth response to unfolded protein blood coagulation protein secretion multicellular organism aging regulation of gene expression vascular associated smooth muscle contraction protein processing collagen fibril organization bone mineralization regulation of bone mineralization BMP signaling pathway multicellular organism growth chondrocyte proliferation tendon development skin development artery morphogenesis musculoskeletal movement neuromuscular process cartilage development bone morphogenesis platelet aggregation vascular associated smooth muscle cell development bone growth negative regulation of hemostasis positive regulation of chondrocyte proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1311 12845 Ensembl ENSG00000105664 ENSMUSG00000031849 UniProt P49747 Q9R0G6 RefSeq (mRNA) NM_000095 NM_016685 RefSeq (protein) NP_000086 NP_057894 Location (UCSC) Chr 19: 18.78 – 18.79 Mb Chr 8: 70.83 – 70.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein.^[8] It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).^[7]

COMP is a marker of cartilage turnover.^[9] It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.^[10]