COP9 signalosome complex subunit 3

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.^[5][6][7] It encodes a subunit of the COP9 signalosome.

COPS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4WSN
Identifiers
Aliases	COPS3, CSN3, SGN3, COP9 signalosome subunit 3
External IDs	OMIM: 604665; MGI: 1349409; HomoloGene: 2710; GeneCards: COPS3; OMA:COPS3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 17,246,616 bp[1] End 17,281,273 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 59,817,795 bp[2] End 59,839,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle gonad muscle of thigh ganglionic eminence right testis left testis skeletal muscle tissue Skeletal muscle tissue of rectus abdominis vastus lateralis muscle muscle of arm Top expressed in spermatocyte facial motor nucleus medial ganglionic eminence spermatid abdominal wall mandibular prominence maxillary prominence intercostal muscle primitive streak endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component COP9 signalosome nucleus nucleoplasm cytoplasm cytosol Biological process transcription-coupled nucleotide-excision repair in utero embryonic development ubiquitin-dependent protein catabolic process nucleotide-excision repair, DNA damage recognition signal transduction response to light stimulus protein deneddylation post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8533 26572 Ensembl ENSG00000141030 ENSMUSG00000019373 UniProt Q9UNS2 O88543 RefSeq (mRNA) NM_001199125 NM_003653 NM_001316354 NM_001316355 NM_001316356 NM_001316357 NM_001316358 NM_011991 RefSeq (protein) NP_001186054 NP_001303283 NP_001303284 NP_001303285 NP_001303286 NP_001303287 NP_003644 NP_036121 Location (UCSC) Chr 17: 17.25 – 17.28 Mb Chr 11: 59.82 – 59.84 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[7]

See also

• Signalosome