CORO1B

Coronin, actin binding protein, 1B also known as CORO1B is a protein which in humans is encoded by the CORO1B gene.^[1] Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility.^[2]

coronin, actin binding protein, 1B
Identifiers
Symbol	CORO1B
NCBI gene	57175
HGNC	2253
OMIM	609849
RefSeq	NM_020441
UniProt	Q9BR76
Other data
Locus	Chr. 11 q13.1
Search for Structures Swiss-model Domains InterPro

Function

A mammalian coronin enriches at the leading edge of migrating cells.^[3] Studies related to this protein are as follows:

• Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.^[4]
• F-actin binding is essential for coronin 1B function in vivo.^[5]
• Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.^[6]
• Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.^[2]
• In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.^[7]
• Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.^[8]