Carboxypeptidase A2

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene.^[5][6][7]

CPA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AYE, 1DTD, 1O6X
Identifiers
Aliases	CPA2, carboxypeptidase A2
External IDs	OMIM: 600688; MGI: 3617840; HomoloGene: 37541; GeneCards: CPA2; OMA:CPA2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.2 Start 130,266,863 bp[1] End 130,289,798 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 30,541,581 bp[2] End 30,564,475 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans pancreatic epithelial cell body of stomach beta cell duodenum testicle C1 segment fundus jejunal mucosa Top expressed in pyloric antrum islet of Langerhans embryo duodenum retinal pigment epithelium genital tubercle saccule sexually immature organism migratory enteric neural crest cell embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carboxypeptidase activity metallopeptidase activity zinc ion binding peptidase activity hydrolase activity metallocarboxypeptidase activity metal ion binding Cellular component extracellular region vacuole extracellular space Biological process proteolysis protein catabolic process in the vacuole Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1358 232680 Ensembl ENSG00000158516 ENSMUSG00000071553 UniProt P48052 Q504N0 RefSeq (mRNA) NM_001869 NM_001024698 RefSeq (protein) NP_001860 NP_001019869 Location (UCSC) Chr 7: 130.27 – 130.29 Mb Chr 6: 30.54 – 30.56 Mb PubMed search [3] [4]
Wikidata
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Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues^[7]