CPSF2

Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene.^[5][6][7] This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation.^[8] The CPSF2 protein connects the two subunits of the complex, mCF and mPSF.^[8] Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function.^[9] This protein has been identified as an essential subunit of the complex as certain mutations in the region inhibit CPSF complex formation.^[9]

PDB-6V4X. CPSF2 protein highlighted within the CPSF complex. CPSF2 is rainbow colored. Other subunits of the complex are represented by solid colors.

CPSF2
Identifiers
Aliases	CPSF2, CPSF100, cleavage and polyadenylation specific factor 2
External IDs	OMIM: 606028; MGI: 1861601; HomoloGene: 6460; GeneCards: CPSF2; OMA:CPSF2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 92,121,969 bp[1] End 92,172,145 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 101,942,247 bp[2] End 101,972,683 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell tendon of biceps brachii epithelium of colon islet of Langerhans stromal cell of endometrium Achilles tendon skin of arm ventricular zone appendix monocyte Top expressed in Ileal epithelium Rostral migratory stream tail of embryo genital tubercle lumbar spinal ganglion medial ganglionic eminence embryonic cell migratory enteric neural crest cell zygote human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component mRNA cleavage and polyadenylation specificity factor complex membrane nucleus nucleoplasm Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA polyadenylation mRNA processing mRNA cleavage mRNA 3'-end processing by stem-loop binding and cleavage mRNA 3'-end processing mRNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53981 51786 Ensembl ENSG00000165934 ENSMUSG00000041781 UniProt Q9P2I0 O35218 RefSeq (mRNA) NM_017437 NM_001322270 NM_001322271 NM_001322272 NM_016856 RefSeq (protein) NP_001309199 NP_001309200 NP_001309201 NP_059133 NP_058552 Location (UCSC) Chr 14: 92.12 – 92.17 Mb Chr 12: 101.94 – 101.97 Mb PubMed search [3] [4]
Wikidata
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