CPSF1

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.^[5][6][7]

CPSF1
Identifiers
Aliases	CPSF1, CPSF160, HSU37012, P/cl.18, cleavage and polyadenylation specific factor 1
External IDs	OMIM: 606027; MGI: 2679722; HomoloGene: 40865; GeneCards: CPSF1; OMA:CPSF1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,393,229 bp[1] End 144,409,349 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,480,003 bp[2] End 76,491,791 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right hemisphere of cerebellum right uterine tube granulocyte pituitary gland anterior pituitary duodenum mucosa of transverse colon spleen Top expressed in internal carotid artery external carotid artery hair follicle primitive streak vestibular membrane of cochlear duct endothelial cell of lymphatic vessel epiblast neural layer of retina ventricular zone adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding enzyme binding protein binding mRNA 3'-UTR AU-rich region binding RNA binding Cellular component mRNA cleavage and polyadenylation specificity factor complex nucleus nucleoplasm Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA polyadenylation mRNA processing mRNA cleavage mRNA 3'-end processing mRNA export from nucleus pre-mRNA cleavage required for polyadenylation tRNA splicing, via endonucleolytic cleavage and ligation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29894 94230 Ensembl ENSG00000071894 ENSMUSG00000034022 UniProt Q10570 Q9EPU4 RefSeq (mRNA) NM_013291 NM_001164173 NM_053193 NM_001361485 RefSeq (protein) NP_037423 NP_001157645 NP_444423 NP_001348414 Location (UCSC) Chr 8: 144.39 – 144.41 Mb Chr 15: 76.48 – 76.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and located in the nucleus.^[8]