Δ-Catenin

δ-Catenin is a subfamily of catenin proteins with ten armadillo-repeats and includes the proteins catenin delta-1 and catenin delta-2. Catenin delta-2 is expressed in the brain where it is important for normal cognitive development.^[1] Like β-catenin and γ-catenin, δ-catenins seem to interact with presenilins.^[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.^[3]

catenin (cadherin-associated protein), delta 1
Identifiers
Symbol	CTNND1
Alt. symbols	CTNND
NCBI gene	1500
HGNC	2515
OMIM	601045
RefSeq	NM_001331
UniProt	O60716
Other data
Locus	Chr. 11 q12.1
Search for Structures Swiss-model Domains InterPro

catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Identifiers
Symbol	CTNND2
NCBI gene	1501
HGNC	2516
OMIM	604275
RefSeq	NM_001332
UniProt	Q9UQB3
Other data
Locus	Chr. 5 p15.2
Search for Structures Swiss-model Domains InterPro

While β-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-1 catenin has been implicated as a regulator of the NF-κB transcription factor.^[4]

Palmitoylation of δ-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.^[5]