P120 catenin

p120 catenin, or simply p120, also called catenin delta-1, is a protein that in humans is encoded by the CTNND1 gene.^[5]

CTNND1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L6X, 3L6Y
Identifiers
Aliases	CTNND1, CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), catenin delta 1, BCDS2
External IDs	OMIM: 601045; MGI: 105100; HomoloGene: 1017; GeneCards: CTNND1; OMA:CTNND1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 57,753,243 bp[1] End 57,819,546 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 D|2 49.45 cM Start 84,430,415 bp[2] End 84,481,109 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone mucosa of esophagus epithelium of colon placenta skin of abdomen skin of leg rectum body of pancreas minor salivary glands sural nerve Top expressed in tail of embryo genital tubercle ovary jejunum placenta ileum colon lip esophagus lung More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding signaling receptor binding protein kinase binding cell adhesion molecule binding cadherin binding Cellular component cytoplasm cytosol membrane cell-cell junction growth cone plasma membrane dendritic spine synapse midbody zonula adherens extracellular exosome nucleus lamellipodium catenin complex Schaffer collateral - CA1 synapse hippocampal mossy fiber to CA3 synapse presynaptic active zone cytoplasmic component glutamatergic synapse postsynaptic density, intracellular component Biological process regulation of transcription, DNA-templated Wnt signaling pathway transcription, DNA-templated brain development cell adhesion adherens junction organization negative regulation of canonical Wnt signaling pathway entry of bacterium into host cell cell-cell adhesion cell-cell junction assembly regulation of postsynaptic membrane neurotransmitter receptor levels Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1500 12388 Ensembl ENSG00000198561 ENSMUSG00000034101 UniProt O60716 P30999 RefSeq (mRNA) NM_001331 NM_001085458 NM_001085459 NM_001085460 NM_001085461 NM_001085462 NM_001085463 NM_001085464 NM_001085465 NM_001085466 NM_001085467 NM_001085468 NM_001085469 NM_001206883 NM_001206884 NM_001206885 NM_001206886 NM_001206887 NM_001206888 NM_001206889 NM_001206890 NM_001206891 NM_001085448 NM_001085449 NM_001085450 NM_001085453 NM_007615 NM_001355064 NM_001355065 NM_001355066 NM_001355067 RefSeq (protein) NP_001078927 NP_001078928 NP_001078929 NP_001078930 NP_001078931 NP_001078932 NP_001078933 NP_001078934 NP_001078935 NP_001078936 NP_001078937 NP_001078938 NP_001193812 NP_001193813 NP_001193814 NP_001193815 NP_001193816 NP_001193817 NP_001193818 NP_001193819 NP_001193820 NP_001322 NP_001078917 NP_001078918 NP_001078919 NP_001078922 NP_031641 NP_001341993 NP_001341994 NP_001341995 NP_001341996 Location (UCSC) Chr 11: 57.75 – 57.82 Mb Chr 2: 84.43 – 84.48 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.^[6]

Clinical significance

Immunohistochemistry for p120 has cytoplasmic staining in invasive lobular carcinoma (shown), but has membranous staining in invasive ductal carcinoma, thereby helping to distinguish these cancer types.

Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.^[7]

Interactions

CTNND1 has been shown to interact with:

• β-Catenin,^[8][9]
• CDH1,^{[8][10][11][12][13][14][15][16]}
• CDH2,^[17][18]
• Collagen, type XVII, alpha 1,^[19]
• Cortactin,^[20]
• FYN,^[10][20]
• MUC1,^[21]
• Nephrin,^[22]
• PSEN1,^[23]
• PTPN6,^[24]
• PTPRJ,^[25]
• PTPRM,^[26]
• VE-cadherin,^[27][28]
• YES1,^[10] and
• ZBTB33^[29]

See also

• δ-Catenin
• Catenin
• CTNND2