Cathepsin L2

"CTSV" redirects here. For the car, see Cadillac CTS-V.

Cathepsin L2 (EC 3.4.22.43, also known as cathepsin V or cathepsin U) is a protein encoded in humans by the CTSV gene.^[5][6][7][8]

CTSV
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FH0, 3H6S, 3KFQ
Identifiers
Aliases	CTSV, cathepsin V, CATL2, CTSL2, CTSU
External IDs	OMIM: 603308; MGI: 88564; HomoloGene: 76699; GeneCards: CTSV; OMA:CTSV - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.33 Start 97,029,677 bp[1] End 97,156,556 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B3|13 33.26 cM Start 64,507,151 bp[2] End 64,518,704 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus skin of arm skin of thigh oocyte retinal pigment epithelium amniotic fluid secondary oocyte hair follicle vulva gonad Top expressed in stroma of bone marrow iris epithelium of lens decidua endothelial cell of lymphatic vessel gastrula corneal stroma ciliary body efferent ductule cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity peptide binding peptidase activity protein binding aminopeptidase activity hydrolase activity serine-type endopeptidase activity cysteine-type endopeptidase activity cysteine-type carboxypeptidase activity histone binding kininogen binding protein-containing complex binding Cellular component cytoplasm perikaryon apical part of cell secretory granule extracellular region microvillus vacuole lysosomal lumen neuron projection lysosome external side of plasma membrane extracellular space nucleus nucleolus cytoplasmic vesicle Biological process male gonad development response to organic cyclic compound antigen processing and presentation of exogenous peptide antigen via MHC class II cellular response to starvation extracellular matrix disassembly response to glucocorticoid response to glucose Sertoli cell differentiation response to gonadotropin proteolysis cell communication decidualization spermatogenesis multicellular organism aging proteolysis involved in cellular protein catabolic process nerve development autophagic cell death response to odorant regulation of keratinocyte differentiation negative regulation of keratinocyte proliferation protein processing protein autoprocessing hair follicle morphogenesis regulation of actin cytoskeleton reorganization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1515 13039 Ensembl ENSG00000136943 ENSMUSG00000021477 UniProt O60911 P06797 RefSeq (mRNA) NM_001333 NM_001201575 NM_009984 RefSeq (protein) NP_001188504 NP_001324 NP_034114 Location (UCSC) Chr 9: 97.03 – 97.16 Mb Chr 13: 64.51 – 64.52 Mb PubMed search [3] [4]
Wikidata
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The protein is a human cysteine cathepsin, a lysosomal cysteine protease with endopeptidase activity.

The protein is a member of the papain-like protease family (MEROPS family C1), a lysosomal cysteine protease with endopeptidase activity. It may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Clinical significance

Cathepsin L2 may play a role in the pathogenesis of keratoconus.^[9]