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Cubilin
Mammalian protein found in humans From Wikipedia, the free encyclopedia
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Cubilin is a protein that in humans is encoded by the CUBN gene.[5][6][7] It is present upon the luminal surface of enterocytes of the ileum where it facilitates absorption of vitamin B12 by acting as a receptor for IF-cobalamin (intrinsic factor - vitamin B12) complexes, enabling endocytosis of complexes by means of amnionless (AMN).[8][9]
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Biochemistry
Cubilinis essentially only present in the small intestine and kidneys.[10]
A complex of amnionless and cubilin forms the cubam receptor.[citation needed]
Clinical significance
Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.[7]
Cubilin is a potential diagnostic and prognostic cancer biomarker for kidney cancer.[11] Based on patient survival data, high levels of cubilin in tumor cells is a favourable prognostic biomarker in renal cell carcinoma.[12][13]
References
Further reading
External links
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