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Cubilin

Mammalian protein found in humans From Wikipedia, the free encyclopedia

Cubilin
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Cubilin is a protein that in humans is encoded by the CUBN gene.[5][6][7] It is present upon the luminal surface of enterocytes of the ileum where it facilitates absorption of vitamin B12 by acting as a receptor for IF-cobalamin (intrinsic factor - vitamin B12) complexes, enabling endocytosis of complexes by means of amnionless (AMN).[8][9]

Quick Facts CUBN, Available structures ...
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Biochemistry

Cubilinis essentially only present in the small intestine and kidneys.[10]

A complex of amnionless and cubilin forms the cubam receptor.[citation needed]

Clinical significance

Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.[7]

Cubilin is a potential diagnostic and prognostic cancer biomarker for kidney cancer.[11] Based on patient survival data, high levels of cubilin in tumor cells is a favourable prognostic biomarker in renal cell carcinoma.[12][13]

References

Further reading

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