CXCL14

Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine).^[1] Mature CXCL14 has many of the conserved features of the CXC chemokine subfamily but has some differences too, such as a shorter N-terminus and five extra amino acids in the region between its third and fourth cysteines.^[1] CXCL14 is constitutively expressed at high levels in many normal tissues, where its cellular source is thought to be fibroblasts.^[2] However, it is reduced or absent from most cancer cells.^[1][3] This chemokine is chemotactic for monocytes and can activate these cells in the presence of an inflammatory mediator called prostaglandin-E2 (PGE2).^[2] It is also a potent chemoattractant and activator of dendritic cells, is implicated in homing of these cells,^[4] and can stimulate the migration of activated NK cells.^[5] CXCL14 also inhibits angiogenesis, possibly as a result of its ability to block endothelial cell chemotaxis.^[6] The gene for CXCL14 contains four exons and is located on chromosome 5 in humans.^[1]

chemokine (C-X-C motif) ligand 14
Identifiers
Symbol	CXCL14
Alt. symbols	SCYB14, BRAK, NJAC, bolekine, Kec, MIP-2g, BMAC, KS1
NCBI gene	9547
HGNC	10640
OMIM	604186
PDB	2HDL
RefSeq	NM_004887
UniProt	O95715
Other data
Locus	Chr. 5 q31
Search for Structures Swiss-model Domains InterPro

Visualization of crystallized protein CXCL14.