Cytokine-like protein 1

Cytokine-like protein 1 (also protein C17) is a protein that in humans is encoded by the CYTL1 gene.^[5]

CYTL1
Identifiers
Aliases	CYTL1, C17, C4orf4, cytokine like 1
External IDs	OMIM: 607930; MGI: 2684993; HomoloGene: 10254; GeneCards: CYTL1; OMA:CYTL1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.2 Start 5,014,586 bp[1] End 5,019,458 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 37,892,863 bp[2] End 37,897,164 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia trachea ascending aorta Descending thoracic aorta cartilage tissue trabecular bone canal of the cervix popliteal artery tibial arteries ectocervix Top expressed in skin of external ear intercostal muscle interventricular septum ankle basilar part of occipital bone aorta laryngeal cartilages right lung lobe stria vascularis aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding Cellular component extracellular region extracellular space Biological process inner ear development chondroitin sulfate proteoglycan biosynthetic process positive regulation of DNA-binding transcription factor activity cartilage homeostasis chondrocyte differentiation signal transduction positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54360 231162 Ensembl ENSG00000170891 ENSMUSG00000062329 UniProt Q9NRR1 A1E5L0 RefSeq (mRNA) NM_018659 NM_001081106 RefSeq (protein) NP_061129 NP_001074575 Location (UCSC) Chr 4: 5.01 – 5.02 Mb Chr 5: 37.89 – 37.9 Mb PubMed search [3] [4]
Wikidata
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Function

Protein C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 surface marker.^[6] Functionally, C17 was identified as a secretory protein expressed in CD34+ haemopoietic cells.^[6] CYTL1 seems to regulate chondrogenesis and is required for the maintenance of cartilage homeostasis and might, additionally, work as a regulatory factor in embryo implantation in the stage of early pregnancy.^[7]

This family of proteins, C17, is found in vertebrates. Proteins have two conserved sequence motifs: PPTCYSR and DDC.