Cadherin cytoplasmic region

In molecular biology, the cadherin cytoplasmic region is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region (the part of the cytoplasmic region which is adjacent to the transmembrane domain) of the cadherin. This region induces clustering and also binds to the protein catenin (p120ctn).^[1] The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton.^[2]

Cadherin_C
beta-catenin/e-cadherin complex
Identifiers
Symbol	Cadherin_C
Pfam	PF01049
InterPro	IPR000233
SCOP2	1i7w / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

See also

• Protocadherin, a different, unrelated cytoplasmic region