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Cannabidiphorol

Chemical compound From Wikipedia, the free encyclopedia

Cannabidiphorol
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Cannabidiphorol, the heptyl-homologue of cannabidiol was identified as a natural phytocannabinoid and named cannabidiphorol (CBDP) in 2019.[1] It had previously been reported as a synthetic compound,[2] but was not identified as a natural product prior to 2019. Recently, CBDP has been gained popularity due to it being synthesized and available on a commercial level.[3]

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Pharmacology

Pharmacodynamics

CBDP shows weak antagonism at both cannabinoid receptors (CB1 and CB2), similar to cannabidiol (CBD). CBD, however, exhibits stronger antagonism at CB2, reaching a 33% maximum response of SR144528 versus CBDP's 23%.[4]

Both cannabinoids act as weak agonists at the serotonin 5-HT1A receptor, contributing to potential anxiolytic effects.[4]

Unlike CBD, CBDP shows no sign of dopamine D2 receptor agonism.[4]

Unexpectedly, CBDP acts as a positive allosteric modulator (PAM) at the MOR, enhancing met-enkephalin signaling by 37%, potentially affecting pain perception.[4]

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References

See also

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