Cbl TKB domain

In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. This N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues.^[1][2]

CBL proto-oncogene N-terminal domain 1 (four-helix bundle)
structure of the n-terminal domain of cbl in complex with its binding site in zap-70
Identifiers
Symbol	Cbl_N
Pfam	PF02262
InterPro	IPR003153
SCOP2	1b47 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

CBL proto-oncogene N-terminus, EF hand-like domain
structure of the n-terminal domain of cbl in complex with its binding site in zap-70
Identifiers
Symbol	Cbl_N2
Pfam	PF02761
InterPro	IPR014741
SCOP2	1b47 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

CBL proto-oncogene N-terminus, SH2-like domain
structure of the n-terminal domain of cbl in complex with its binding site in zap-70
Identifiers
Symbol	Cbl_N3
Pfam	PF02762
InterPro	IPR014742
SCOP2	1b47 / SCOPe / SUPFAM
CDD	cd09920
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary