Chlorophyllide-a oxygenase

Chlorophyllide-a oxygenase (EC 1.14.13.122), chlorophyllide a oxygenase, chlorophyll-b synthase, CAO) is an enzyme with systematic name chlorophyllide-a:oxygen 7-oxidoreductase.^[1][2][3][4] This enzyme catalyses the following chemical reactions

(1) chlorophyllide a + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ 7-hydroxychlorophyllide a + H₂O + NADP⁺

(2) 7-hydroxychlorophyllide a + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ chlorophyllide b + 2 H₂O + NADP⁺

Chlorophyllide a, (R=H) is converted to chlorophyllide b, in which the methyl group show in the green box is oxidised to a formyl group.

Chlorophyllide-a oxygenase
Identifiers
EC no.	1.14.13.122
CAS no.	216503-73-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme contains a mononuclear iron centre and is part of the biosynthetic pathway to chlorophylls.^[5][6]

See also

• Biosynthesis of chlorophylls