Cholecystokinin receptor

Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.^[1] There are two different subtypes CCK_A and CCK_B which are ~50% homologous:^[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.

Protein	Gene	Tissue distribution	Preferred ligand	Function	Mechanism
CCKA (CCK1)	CCKAR	primarily gastrointestinal tract, lesser amounts in the CNS	sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK	stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility	Gq[3][4]
CCKB (CCK2)	CCKBR	primarily CNS, lesser amounts in the gastrointestinal tract	gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides)	regulation of nociception, anxiety, memory and hunger	Gq/G11[4]

cholecystokinin A receptor
Identifiers
Symbol	CCKAR
NCBI gene	886
HGNC	1570
OMIM	118444
RefSeq	NM_000730
UniProt	P32238
Other data
Locus	Chr. 4 p15.2-p15.1
Search for Structures Swiss-model Domains InterPro

cholecystokinin B receptor
Identifiers
Symbol	CCKBR
NCBI gene	887
HGNC	1571
OMIM	118445
RefSeq	NM_176875
UniProt	P32239
Other data
Locus	Chr. 11 p15.4
Search for Structures Swiss-model Domains InterPro