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Chronic allograft nephropathy

Medical condition From Wikipedia, the free encyclopedia

Chronic allograft nephropathy
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Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure,[1] occurring months to years after the transplant.

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Symptoms and signs

CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.[2]

Pathology

The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.[2][3]

Diagnosis

CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.[4]

References

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