Ciclafrine

Ciclafrine (INNTooltip International Nonproprietary Name; developmental code names Go 3026A, W-43026A) is a sympathomimetic and antihypotensive agent of the phenethylamine family that was never marketed.^[1][2][3][4]

Ciclafrine

Clinical data
Other names	Go 3026A; W-43026A
ATC code	None
Identifiers
IUPAC name 3-(1-Oxa-4-azaspiro[4.6]undec-2-yl)phenol
CAS Number	55694-98-9
PubChem CID	193971
ChemSpider	168322
UNII	76HZX0GVCD
ChEMBL	ChEMBL2110798
CompTox Dashboard (EPA)	DTXSID60971060
Chemical and physical data
Formula	C15H21NO2
Molar mass	247.338 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1cc(cc(c1)O)C2CNC3(O2)CCCCCC3
InChI InChI=1S/C15H21NO2/c17-13-7-5-6-12(10-13)14-11-16-15(18-14)8-3-1-2-4-9-15/h5-7,10,14,16-17H,1-4,8-9,11H2 Key:AJNAKEPPGKJNKU-UHFFFAOYSA-N

Chemistry

Ciclafrine is a substituted phenethylamine and belongs to the class of hemiaminal ethers.

Synthesis

Ciclafrine can be prepared by the reaction of norfenefrine with cycloheptanone.^[5]

Ciclafrine synthesis

See also

• Berefrine