Clavaminate synthase

Clavaminate synthase (EC 1.14.11.21, clavaminate synthase 2, clavaminic acid synthase) is an enzyme with systematic name deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating).^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

(1) deoxyamidinoproclavaminate + 2-oxoglutarate + O₂ ${\displaystyle \rightleftharpoons }$ amidinoproclavaminate + succinate + CO₂

(2) proclavaminate + 2-oxoglutarate + O₂ ${\displaystyle \rightleftharpoons }$ dihydroclavaminate + succinate + CO₂ + H₂O

(3) dihydroclavaminate + 2-oxoglutarate + O₂ ${\displaystyle \rightleftharpoons }$ clavaminate + succinate + CO₂ + H₂O

Clavaminate synthase
Identifiers
EC no.	1.14.11.21
CAS no.	122799-56-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Clavaminate synthase contains nonheme iron.