Co-danthrusate

Co-danthrusate is a combination of dantron and docusate. Dantron is a mild peristaltic stimulant which acts on the lower bowel to encourage normal bowel movement without causing irritation. It belongs to the group of medicines under the term stimulant laxative.^[1] It stimulates the nerves in the stomach wall, which causes the stomach muscles to contract. This medicine is used for analgesic-induced constipation. It takes six to twelve hours to work.^[2] This can cause discoloration of urine and bowel and liver tumors.^[3]

Co-danthrusate

Combination of
Dantron	stimulant laxative
Docusate	laxative
Identifiers
CAS Number	117-10-2 Y
ChemSpider	none
UNII	Z4XE6IBF3V

Co-danthramer is dantron plus poloxamer. It is (in the U.K.) only to be prescribed to terminally ill patients because of its carcinogenicity in rats. It is often prescribed to people taking long term opioid, because it relaxes the effect of opioid induced constipation. It will not alleviate the symptoms of opioid induced delayed gastric emptying and abdominal cramps.^[4]

See also

• Laxative
• Opioid