Cobalt-precorrin-5B (C1)-methyltransferase

Cobalt-precorrin-5B (C¹)-methyltransferase (EC 2.1.1.195), cobalt-precorrin-6A synthase, CbiD (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:cobalt-precorrin-5B (C¹)-methyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

cobalt-precorrin-5B + S-adenosyl-L-methionine ${\displaystyle \rightleftharpoons }$ cobalt-precorrin-6A + S-adenosyl-L-homocysteine

Cobalt-precorrin-5B (C1)-methyltransferase
Identifiers
EC no.	2.1.1.195
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic pathway^[3] of adenosylcobalamin biosynthesis in bacteria such as Salmonella typhimurium, Bacillus megaterium, and Propionibacterium freudenreichii subsp. shermanii.

See also

• Cobalamin biosynthesis