Cobyrinate a,c-diamide synthase

Cobyrinate a,c-diamide synthase (EC ), cobyrinic acid a,c-diamide synthetase, CbiA (gene)) is an enzyme which catalyses the chemical reaction^[1]

2 ATP + cobyrinate + 2 L-glutamine + 2 H₂O ${\displaystyle \rightleftharpoons }$ 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate (overall reaction)

(1a) ATP + cobyrinate + L-glutamine + H₂O ${\displaystyle \rightleftharpoons }$ ADP + phosphate + cobyrinate c-monamide + L-glutamate

(1b) ATP + cobyrinate c-monamide + L-glutamine + H₂O ${\displaystyle \rightleftharpoons }$ ADP + phosphate + cobyrinate a,c-diamide + L-glutamate

Cobyrinate a,c-diamide synthase
Identifiers
EC no.	6.3.5.11
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is a glutamine amidotransferase, part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.

See also

• Cobalamin biosynthesis