Cod-THC

Cod-THC (Codeine Δ⁹-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.^[1][2][3]

Cod-THC

Identifiers
IUPAC name [(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] [(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-yl] carbonate
PubChem CID	143656467
Chemical and physical data
Formula	C40H49NO6
Molar mass	639.833 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CC[C@@]23c4c5C[C@@H]1[C@@H]2C=C[C@H](OC(=O)Oc1cc(CCCCC)cc2OC(C)(C)[C@@H]6CCC(C)=C[C@H]6c21)[C@@H]3Oc4c(OC)cc5
InChI InChI=InChI=1S/C40H49NO6/c1-7-8-9-10-24-20-32(34-26-19-23(2)11-13-27(26)39(3,4)47-33(34)21-24)45-38(42)44-31-16-14-28-29-22-25-12-15-30(43-6)36-35(25)40(28,37(31)46-36)17-18-41(29)5/h12,14-16,19-21,26-29,31,37H,7-11,13,17-18,22H2,1-6H3/t26-,27-,28+,29-,31+,37+,40+/m1/s1 Key:VDTVNOCXWSYPQX-IWHNUUHWSA-N

THC can partially inhibit CYP2D6, which is the enzyme that transforms codeine into its active metabolite morphine.^[4][5] It's not well understood how THC may impact codeines metabolism in humans.

See also

• Benorilate
• Codeine-6-glucuronide
• Fenethylline
• THC-methylcarbonate
• THC-O-acetate
• THC-VHS