Cohesin domain

In molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.^[1]

Cohesin
single cohesin domain from the scaffolding protein cipa of the clostridium thermocellum cellulosome
Identifiers
Symbol	Cohesin
Pfam	PF00963
Pfam clan	CL0203
InterPro	IPR002102
SCOP2	1anu / SCOPe / SUPFAM
CDD	cd08546
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The scaffolding component of the cellulolytic bacterium Clostridium thermocellum is a non-hydrolytic protein which organises the hydrolytic enzymes into a large complex, called the cellulosome. Scaffoldin comprises a series of functional domains, amongst which is a single cellulose-binding domain and nine cohesin domains which are responsible for integrating the individual enzymatic subunits into the complex.