Competition-ChIP

Competition-ChIP is variant of the Chip-Sequencing protocol, used to measure relative binding dynamics of a transcription factor (TF) on DNA.^[1] Since TF occupancy measures are thought to be a poor predictor of TF function at a given locus, Competition-ChIP is much more strongly linked to function than occupancy. The technique was originally developed in Jason D. Lieb's Lab in 2011.