Compound analgesic

Compound analgesics are those with multiple active ingredients; they include many of the stronger prescription analgesics.

Active ingredients that have been commonly used in compound analgesics include:

• aspirin or ibuprofen
• caffeine
• codeine or oxycodone
• paracetamol (acetaminophen)
• phenacetin

There is evidence that a compound of two analgesics with different mechanism of action can have an increased painkilling effect over the sum of the effect of each individual analgesic.^[1]

Several such formulations have disappeared from over-the-counter status in drug store aisles and other retail outlets. One example is APC (aspirin, phenacetin, and caffeine) compound tablets common from the 1940s to 1983; because of harmful side effects of phenacetin, Anacin in the U.S. was reformulated to eliminate it; while Vincent's APC is no longer sold. Some others have been judged to contribute too often to substance abuse.^{[citation needed]}

Lenoltec is a compound analgesic that comes in four strengths:

No.	Acetaminophen mg	Caffeine mg	Codeine mg	DIN
1	300	15	8	00653233
2	300	15	15	00653241
3	300	15	30	00653276
4	300	0	60	00621463

Another example is Bex, a once popular Australian compound analgesic which is no longer sold. It contained 42% aspirin, 42% phenacetin, plus caffeine.^[2]

The United States Food and Drug Administration also now requires that manufacturers of compound analgesics unequivocally state each ingredient's purpose.^{[citation needed]}